The Process of Pubertal Induction in Girls with Turner Syndrome: From Patients’ and Family’s Perspective
Authors' conclusion
The age to initiate puberty pharmacologically and the types of estrogen preparations used for this purpose varied across different age groups, however, with a tendency to mimic physiology and recommended protocols. The timing and mode of PI should aim to maximize intended effects, reduce risks of side effects and be simple to use. The aim should be to meet patients' expectations to ensure that they are not discouraged from taking long-term E-PRT.
Study context
- Population
- Patients with Turner syndrome (TS) and their caregivers
- Participants
- 109 survey respondents
- Outcome
- Process of pubertal induction, satisfaction with breast development and side effects of therapy from patients' and families' perspective
Methodological detailsanonymous survey, 15-question, recruited via social media
- Anonymous survey
- 15-question
- Recruited via social media
Main finding
As reported in the abstract
- Pubertal induction commenced between ages 10 and 16
- 70.6%
- Oral E2 most frequently offered
- 38.5%
- Oral E2 recommended by respondents
- 33.9%
- Most important consideration in choosing a preparation: ease of use
- 41.3%
- Women satisfied with breast development
- 58.7%
Observational data: associations, not effects.
Safety
- Participants reporting no side effects of hormonal therapy
- 41.3%
Original publication
The Process of Pubertal Induction in Girls with Turner Syndrome: From Patients’ and Family’s Perspective. Horm Res Paediatr. Published 17 October 2025. doi:10.
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