Physiological declines in sex steroid exposure in relation to changes in body composition in healthy men—a prospective cohort study
Authors' conclusion
Aging leads to increases in FM indices and insulin resistance, whereas changes in parameters of LM are less unequivocal. In healthy adult men, physiological changes in sex steroid exposure clearly correlate with changes in adiposity but not so with lean mass, insulin resistance, or grip strength.
Study context
- Population
- Healthy men aged 24–46 years, measured at baseline and after ±12 years
- Participants
- 676 men
- Outcome
- Changes in body composition and metabolic health in relation to changes in sex steroid levels
- Follow-up
- ±12 years
Methodological detailslongitudinal
- Longitudinal
Main finding
As reported in the abstract
±12 years
- Mean fat mass, lean mass and homeostasis model assessment for insulin resistance (HOMA-IR) increased
- all P < .001
- Decreasing androgen and sex hormone-binding globulin (SHBG) levels associated with increasing fat mass; decreasing (cF)E2 levels associated with decreasing fat mass
- all P < .005
- Decreasing (cF)E2 levels and increasing SHBG levels associated with decreasing lean mass
- all P < .002
Observational data: associations, not effects.
Original publication
Physiological declines in sex steroid exposure in relation to changes in body composition in healthy men—a prospective cohort study. Eur J Endocrinol. Published 8 June 2023. doi:10.
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