Serum branch-chained amino acids are increased in type 2 diabetes and associated with atherosclerotic cardiovascular disease
Authors' conclusion
Overall, our results indicated that plasma levels of LMWMs measured by 1H-NMR could be potential biomarkers associated with T2D. Moreover, alanine and valine can help in the early detection of the cardiovascular risk associated with this metabolic disease.
Study context
- Population
- Patients attending a university hospital Lipid Unit for metabolic disturbances: T2D (73.9%), obesity (58.7%), hypertension (55.1%)
- Participants
- 307 patients
- Exposure
- Patients with vs without T2D; baseline LMWM levels and incident atherosclerotic cardiovascular disease (ASCVD) in T2D
- Outcome
- Plasma LMWMs (13, by 1H-NMR) and T2D
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
- Branched-chain amino acids (BCAAs) valine, leucine and isoleucine positively associated with several clinical and lipid-related biochemical parameters and inflammatory markers
- p < 0.05
- The three BCAAs associated with diabetes after adjusting for covariates
- p < 0.05
Observational data: associations, not effects.
Further findings
Incident ASCVD in patients with T2D at baseline · 10 years
- Developed ASCVD
- 29 of 185 (15.68%)
- Baseline valine and alanine associated with ASCVD after adjusting for clinical covariates
- P < 0.05
Original publication
Serum branch-chained amino acids are increased in type 2 diabetes and associated with atherosclerotic cardiovascular disease. Cardiovasc Diabetol. Published 14 September 2023. doi:10.
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