Inflammation and oxidative stress markers in type 2 diabetes patients with Advanced Carotid atherosclerosis
Authors' conclusion
Our study is in line with a key role for inflammation in the pathogenesis of diabetic atherosclerosis and highlights the involvement of 2-AA-LPC. Further research is needed to better understand the local processes involved in the alteration of plaque composition in T2DM and to identify potential therapeutic targets.
Study context
- Population
- Elderly, polymedicated patients with advanced carotid atherosclerosis (carotid plaques), with or without T2D
- Exposure
- T2D vs control patients
- Outcome
- Increase of 2-arachidonoyl-lysophatidylcholine (2-AA-LPC) in carotid plaques, and its association with plaque vulnerability and blood and intra-plaque biomarkers
Main finding
As reported in the abstract
2-AA-LPC in carotid plaques
- 2-AA-LPC was significantly enriched in plaques from diabetic patients
- 2-AA-LPC not associated with systemic markers (high-sensitivity C-reactive protein (hsCRP), TG, HDL-C)
- 2-AA-LPC significantly correlated with intra-plaque inflammatory markers (lysophospholipids, 25-hydroxycholesterol)
Observational data: associations, not effects.
Further findings
Systemic markers
- T2DM patients had higher hsCRP and IL-1β, higher oxysterols, increased TG and decreased HDL vs controls
Original publication
Inflammation and oxidative stress markers in type 2 diabetes patients with Advanced Carotid atherosclerosis. Cardiovasc Diabetol. Published 14 September 2023. doi:10.
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