Serum activin A and bone metabolism in patients undergoing hemodialysis
Authors' conclusion
These findings suggest that in patients with kidney failure, elevated activin A may contribute to high bone turnover, although its ability to predict fracture risk appears limited.
Study context
- Population
- Patients undergoing maintenance hemodialysis and healthy individuals
- Participants
- 654 vs 35
- Exposure
- Hemodialysis patients vs healthy individuals; association of serum activin A with bone turnover markers, BMD and fractures
- Hemodialysisn = 654
- Healthy controlsn = 35reference
- Outcome
- Serum activin A
Main finding
As reported in the abstract
P < 0.001
Observational data: associations, not effects.
Further findings
Association of activin A with bone turnover markers
- Higher activin A significantly associated with increased TRACP5b, independent of intact PTH; similar trend for BALP
Characteristics of patients with higher activin A
- Longer dialysis duration, higher prevalence of polycystic kidney disease, higher serum phosphorus and alkaline phosphatase
Metacarpal BMD and fractures
- Activin A not associated with metacarpal BMD, history of fracture or incident fractures
Original publication
Serum activin A and bone metabolism in patients undergoing hemodialysis. Osteoporos Int. Published 16 July 2026. doi:10.
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