Impact of serum 25-hydroxyvitamin D levels on fragility fractures in patients undergoing chronic hemodialysis
Main finding · Fracture risk per 10 nmol/L increment in serum 25(OH)DResult — go to the resultAdjusted hazard ratio 0.83 95% CI 0.68–0.99Authors' conclusion
Lower serum 25(OH)D levels were independently associated with an increased risk of fracture, regardless of traditional fracture risk factors or variables affecting vitamin D status in patients undergoing hemodialysis with impaired renal vitamin D activation.
Study context
- Population
- Stable outpatients undergoing maintenance hemodialysis49 (16.8%) fractures
- Participants
- 292 outpatients
- Exposure
- Lower vs higher serum 25D
- Outcome
- Incidence of new fragility fractures
- Follow-up
- Median 24 months
Methodological detailsmultivariate Cox regression
- Multivariate Cox regression
Main finding
As reported in the abstract
Fracture risk per 10 nmol/L increment in serum 25(OH)D · median 24 months
Adjusted hazard ratio
0.83
95% CI 0.68–0.99
P = 0.046
10 nmol/L increment in 25(OH)D
aHR 0.83 (95% CI 0.68–0.99); P = 0.046
Per 10 nmol/L increment in serum 25, as printed
Observational data: associations, not effects.
Further findings
| Outcome | Lower-25(OH)D | Higher-25(OH)D | aHR (95% CI) | P value | |
|---|---|---|---|---|---|
| Cumulative fracture incidence by median 25(OH)D · median 24 months | 24.3% | 11.9% | 1.87 (1.02–3.42) | P = 0.041 | |
| 0.20.5125Adjusted hazard ratio (log scale) |
Original publication
Impact of serum 25-hydroxyvitamin D levels on fragility fractures in patients undergoing chronic hemodialysis. Osteoporos Int. Published 28 July 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →