Sensitivity to Thyroid Hormones and Reduced Glomerular Filtration in Children and Adolescents with Overweight or Obesity
Authors' conclusion
MReGFR is associated with reduced indices of central sensitivity to TH in euthyroid children and adolescents with OW/OB. This preliminary observation should be confirmed in prospective studies.
Study context
- Population
- Euthyroid children and adolescents with OW/OB aged 6–16 years, seven Italian centers
- Participants
- 788 children
- Exposure
- Mild reduced estimated glomerular filtration rate (MReGFR) vs normal eGFR
- Outcome
- Association between sensitivity to TH (FT3/FT4 ratio; TSHI, TT4RI, TFQI, PTFQI) and MReGFR
Methodological detailsmulticentre
- Multicentre
Main finding
As reported in the abstract
Indices of sensitivity to TH
- OR of MReGFR raised 1.2-3.2-fold per 1 mIU/L increase in TSH, 1 unit in TSH index (TSHI), and PTFQI; not for FT3/FT4 ratio
- MReGFR vs Normal eGFR: P = 0.028
- MReGFR vs Normal eGFR: P = 0.019
- MReGFR vs Normal eGFR: P = 0.031
- MReGFR vs Normal eGFR: P = 0.046
- MReGFR vs Normal eGFR: P = 0.006
Observational data: associations, not effects.
Original publication
Sensitivity to Thyroid Hormones and Reduced Glomerular Filtration in Children and Adolescents with Overweight or Obesity. Horm Res Paediatr. Published 9 October 2023. doi:10.
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