Selenium Supplementation in Patients with Hashimoto Thyroiditis: A Systematic Review and Meta-Analysis of Randomized Clinical Trials
Pooled result · TSH in patients without THRTResult — go to the resultSMD −0.21 CI −0.43 to −0.02Authors' conclusion
In people with HT without THRT, selenium was effective and safe in lowering TSH, TPOAb, and MDA levels. Indications for lowering TPOAb were found independent of THRT.
Study context
- Population
- Patients with Hashimoto thyroiditis (HT), with or without thyroid hormone replacement therapy (THRT); databases searched from inception to January 202335 studies
- Comparison
- Selenium supplementation vs control
- Outcome
- TSH in patients without THRT
Methodological detailsCochrane RoB 2 risk-of-bias assessment, Grading of Recommendations Assessment, Development, and Evaluation (GRADE) certainty rating, 687 records screened, Overall certainty of evidence moderate (GRADE)
- Cochrane RoB 2 risk-of-bias assessment
- GRADE certainty rating
- 687 records screened
- Overall certainty of evidence moderate (GRADE)
Pooled result
As reported in the abstract
SMD
−0.21
CI −0.43 to −0.02
Seleniumvs Control
SMD −0.21 (CI −0.43 to −0.02)
Further pooled results
TPOAb (patients with and without THRT)
- TPOAb decreased, SMD
- −0.96 (−1.36 to −0.56) (CI)
- 29 cohorts; 2358 participants; I2 = 90%
Malondialdehyde (MDA) (patients with and without THRT)
- MDA decreased, SMD
- −1.16 (−2.29 to −0.02) (CI)
- 3 cohorts; 248 participants; I2 = 85%
fT4, T4, fT3, T3, TGAb, thyroid volume, IL-2 and IL-10
- No significant changes in fT4, T4, fT3, T3, TGAb, thyroid volume, IL-2 and IL-10
Safety
| Outcome | OR (CI) | |
|---|---|---|
| Adverse effects | 0.89 (0.46–1.75) | |
| 0.512Odds ratio (log scale) |
- Adverse effects: 16 cohorts; 1339 participants; I2 = 0%; comparable between groups
Original publication
Selenium Supplementation in Patients with Hashimoto Thyroiditis: A Systematic Review and Meta-Analysis of Randomized Clinical Trials. Thyroid. Published 20 January 2024. doi:10.
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