Prevalence and severity of fatigue in treated hypothyroidism: results of a UK survey
Authors' conclusion
Fatigue in treated hypothyroidism is very common, and the FACIT-F scores reported are comparable or worse than those recorded for many other chronic conditions. This study suggests that addressing fatigue in this patient group will be key to improving wellbeing and quality of life.
Study context
- Population
- Patients with primary hypothyroidism/Hashimoto thyroiditis taking thyroid hormone replacement, UK; 98% women, mean treatment duration 10.8 years (SD 9.74)1,251 complete responses
- Participants
- 1,334 patients
- Outcome
- Fatigue (FACIT-F scale)
Methodological detailsonline survey, distributed by two UK patient support organisations
- Online survey
- Distributed by two UK patient support organisations
Main finding
As reported in the abstract
Fatigue (FACIT-F scale) in treated hypothyroidism
Mean FACIT-F fatigue score
20.5
SD: 10.5
Respondents fulfilling criteria for abnormal fatigue
89%
Observational data: associations, not effects.
Further findings
Fatigue scores by age, gender, treatment type or duration
- Not significantly different between respondents of different ages, gender, treatment type or treatment duration
Correlation of FACIT-F scores with self-declared overall health state
- Positive correlation (Pearson r)
- 0.576, P < 0.001
Original publication
Prevalence and severity of fatigue in treated hypothyroidism: results of a UK survey. Eur Thyroid J. Published 29 April 2025. doi:10.
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