Familial Risk of Hashimoto's Thyroiditis in a Large Genealogical Database
Authors' conclusion
This is the first study to estimate an increased risk of HT for second- and third-degree relatives, who are less likely to share common environments than first-degree relatives.
Study context
- Population
- Hashimoto thyroiditis (HT) probands, matched controls and their first-, second- and third-degree relatives, Utah Population Database
- Participants
- 92,405 vs 184,810
- Exposure
- Relatives of HT probands vs relatives of matched controls
- HT probandsn = 92,405
- Controlsn = 184,810reference
- Outcome
- Relative risk (OR) of HT in first-, second- and third-degree relatives
Methodological detailsmatched case-control genealogical study, matched controls, Utah Population Database
- Matched case-control genealogical study
- Matched controls
- Utah Population Database
Main finding
As reported in the abstract
OR of HT in relatives of affected individuals (HT probands)
OR of HT in first-degree relatives
1.77
95% CI 1.74–1.80
OR of HT in second-degree relatives
1.23
95% CI 1.22–1.27
OR of HT in third-degree relatives
1.11
95% CI 1.10–1.12
Observational data: associations, not effects.
Further findings
OR of HT in spouses of HT probands
| OR (95% CI) | ||
|---|---|---|
| Husbands of affected wivesSuggesting a significant environmental component | 1.50 (1.39–1.61) | |
| Wives of affected husbandsSuggesting a significant environmental component | 1.58 (1.47–1.70) | |
| 0.512Odds ratio (log scale) |
Sex ratio of HT
- Females with HT more common than males
- 2.71-fold
Original publication
Familial Risk of Hashimoto's Thyroiditis in a Large Genealogical Database. J Clin Endocrinol Metab. Published 28 April 2025. doi:10.
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