Patients With Persistent Hashimoto-Related Symptoms. Dilemmas in Advice-Giving and Self-Selection for Thyroidectomy. An Observational Study
Authors' conclusion
A grace period of 18 months with biannual follow-up before thyroidectomy may be useful to modify exposure to surgery carrying a certain risk of complications. At 18 months, the fatigue score stands out as the most important factor influencing the odds for maintaining a choice to have surgery.
Study context
- Population
- Patients with persistent Hashimoto disease-related symptoms, highly motivated for thyroidectomy, completing an 18-month watchful waiting period with biannual consultations
- Participants
- 177 patients
- Exposure
- Patients proceeding to thyroidectomy vs those declining surgery after 18-month watchful waiting
- Surgeryn = 131
- No-surgeryn = 46reference
- Outcome
- Proceeded to thyroidectomy
- Follow-up
- 18 months of watchful waiting
Main finding
As reported in the abstract
Proceeded to thyroidectomy
131 (74%) of 177
Declined surgery
46
Observational data: associations, not effects.
Further findings
Sex, age and TPO antibody levels · 18 months watchful waiting
- No difference between surgery and no-surgery groups
PROM scores
- PROM scores consistently poorer in the surgery group vs no-surgery group for all domains
Original publication
Patients With Persistent Hashimoto-Related Symptoms. Dilemmas in Advice-Giving and Self-Selection for Thyroidectomy. An Observational Study. Endocr Pract. Published 21 April 2025. doi:10.
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