Role of metabolic dysfunction-associated steatotic liver disease and of its genetics on kidney function in childhood obesity
Authors' conclusion
The coexistence of more than 1 MASLD criterion in children with obesity seems to adversely affect kidney function. The PNPLA3 I148M allele further impacts on this association.
Study context
- Population
- Children with obesity, genotyped for PNPLA3 I148M; Fatty liver (FL) assessed by liver US
- Participants
- 1,037 children
- Exposure
- Children with obesity without FL vs with FL (1 metabolic associated steatotic liver disease (MASLD) criterion) vs with FL and metabolic dysregulation (>1 MASLD criterion)
- Outcome
- eGFR (kidney function) in relation to MASLD and PNPLA3 I148M
Main finding
As reported in the abstract
eGFR
- General linear model: inverse association of estimated glomerular filtration rate (eGFR) with MASLD
- p = 0.011
- General linear model: inverse association of eGFR with PNPLA3 genotypes
- p = 0.02
- Inverse association of eGFR with MASLD confirmed only in carriers
- p = 0.006
Observational data: associations, not effects.
Further findings
Carriers of PNPLA3 I148M allele
- Higher percentage of carriers in group 3 vs other groups
- P < 0.0001
eGFR in carriers vs noncarriers within groups
- Reduced eGFR in carriers vs noncarriers of group 2
- P = 0.04
- Reduced eGFR in carriers vs noncarriers of group 3
- P = 0.02
Original publication
Role of metabolic dysfunction-associated steatotic liver disease and of its genetics on kidney function in childhood obesity. Int J Obes (Lond). Published 9 November 2024. doi:10.
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