Risks of peri‐ and postoperative complications with glucagon‐like peptide‐1 receptor agonists
Authors' conclusion
No increased risk of peri- and postoperative complications in GLP1-RA users undergoing surgery with general endotracheal anaesthesia was identified.
Study context
- Population
- US adults with diabetes on oral hypoglycaemic agents undergoing general endotracheal anaesthesia during nine common surgical procedures; nationally representative electronic health dataset, 1 January 2015–1 April 202316.5% on GLP1-RA
- Participants
- 13,361 adults
- Exposure
- GLP-1 RA users vs non-users
- Outcome
- Six peri- and postoperative complications: composite of postoperative decelerated gastric emptying (antiemetic use, ileus within 7 days, gastroparesis diagnosis, gastric emptying study); aspiration or pneumonitis; severe respiratory failure; postoperative hypoglycaemia; inpatient mortality; 30-day mortality
Methodological detailsobservational, high-dimensionality propensity score-matched, sensitivity analysis in diabetes and obesity
- Observational
- High-dimensionality propensity score-matched
- Sensitivity analysis in diabetes and obesity
Main finding
As reported in the abstract
Peri- and postoperative complications
- Lower risk of decelerated gastric emptying and antiemetic use with GLP1-RA users vs non-users
- Risk of ileus within 7 days, aspiration/pneumonitis, hypoglycaemia and 30-day mortality not different
- High-dimensionality propensity score-matched cohort
Observational data: associations, not effects.
Further findings
Sensitivity analysis: patients with diabetes and obesity
- Similar findings in patients with diabetes and obesity
Original publication
Risks of peri‐ and postoperative complications with glucagon‐like peptide‐1 receptor agonists. Diabetes Obes Metab. Published 14 May 2024. doi:10.
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