Identification of a Common Variant for Coronary Heart Disease at PDE1A Contributes to Individualized Treatment Goals and Risk Stratification of Cardiovascular Complications in Chinese Patients With Type 2 Diabetes
Authors' conclusion
We discovered a novel CHD- and BP-related variant at PDE1A that interacted with BP goal attainment with divergent effects on CHD risk in Chinese patients with T2D. Incorporating this information may facilitate individualized treatment strategies for precision care in diabetes, only when our findings are validated.
Study context
- Population
- Chinese patients with T2D (3,596 cases and 8,898 controls); replication in European patients with T2D (764 cases and 4,276 controls) and general populations (n = 51,442–547,261)
- Outcome
- Genetic determinants of CHD in T2D
Methodological detailstwo-stage, replication in European T2D patients and general populations
- Two-stage
- Replication in European T2D patients and general populations
Main finding
As reported in the abstract
Novel variant rs10171703 at PDE1A, Chinese T2D patients
rs10171703 and coronary heart disease (CHD), OR
1.21
95% CI 1.13–1.30P = 2.4 × 10-8
rs10171703 and blood pressure (BP), β ± SE (P = 4.1 × 10-14)
0.130 ± 0.017
Further findings
Interaction of rs10171703 with BP goal attainment (130/80 mmHg)
- Pinteraction, CHD
- 0.0155
- Pinteraction, myocardial infarction (MI)
- 5.1 × 10-4
- TT genotype: threefold increase in MI risk (P = 6.7 × 10-3)
- threefold
- CC genotype: >40% reduction in either cardiovascular events with BP control (2.9 × 10-8 < P < 3.6 × 10-5)
- CT genotype: no difference (0.0726 < P < 0.2614)
Original publication
Identification of a Common Variant for Coronary Heart Disease at PDE1A Contributes to Individualized Treatment Goals and Risk Stratification of Cardiovascular Complications in Chinese Patients With Type 2 Diabetes. Diabetes Care. Published 1 May 2023. doi:10.
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