Association and Interaction of Genetics and Area-Level Socioeconomic Factors on the Prevalence of Type 2 Diabetes and Obesity
Authors' conclusion
Genetic and socioeconomic factors significantly interact to increase risk of T2D and obesity. Favorable area-level socioeconomic status was associated with an almost 50% lower T2D prevalence in those with high genetic risk.
Study context
- Population
- Participants of European genetic ancestry in the Mass General Brigham Biobank (MGBB), with replication in UK Biobank (UKB) and in participants of non-European ancestryEuropean ancestry, MGBB
- Participants
- 26,737 participants
- Exposure
- Highest vs lowest quintiles of combined genetic and area-level socioeconomic burden
- Outcome
- Cross-sectional odds of T2D and obesity by polygenic risk scores for T2D and BMI and area-level socioeconomic risk (educational attainment)
Methodological detailsbiobank-based, logistic regression, replication cohorts
- Biobank-based
- Logistic regression
- Replication cohorts
Main finding
As reported in the abstract
T2D and obesity prevalence by combined genetic and socioeconomic burden
- Percent without a college degree most strongly associated with T2D and obesity; associations independent of genetic risk
- P < 0.001 for each
- T2D prevalence, lowest to highest combined burden quintile
- 3.1% to 22.2%
- Obesity prevalence, lowest to highest combined burden quintile
- 20.9% to 69.0%
Observational data: associations, not effects.
Further findings
Prevalence in highest genetic risk, lowest vs highest socioeconomic risk quintiles
- T2D, lowest vs highest socioeconomic risk quintile
- 13.0% vs. 22.2%
- Obesity, lowest vs highest socioeconomic risk quintile
- 53.6% vs. 69.0%
Prevalence explained by additive genetic and socioeconomic effects
- T2D
- 13.2%
- Obesity
- 16.7%
Replication
- Replication in UKB European ancestry
- N = 223,843
- Replication in non-European ancestry, MGBB
- N = 3,468
- Replication in non-European ancestry, UKB
- N = 7,459
- Findings replicated in independent European and non-European ancestral populations
Original publication
Association and Interaction of Genetics and Area-Level Socioeconomic Factors on the Prevalence of Type 2 Diabetes and Obesity. Diabetes Care. Published 14 February 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →