Risk of rotator cuff tear and rotator cuff repair surgery comparison between sodium-glucose cotransporter 2 inhibitors and glucagon like peptide-1 receptor agonists: A real-world study
Authors' conclusion
SGLT2is appear to reduce the risk of rotator cuff tear and the risk of receiving rotator cuff repair surgery in patients with type 2 diabetes mellitus. Further prospective studies are needed to validate our findings.
Study context
- Population
- Patients with T2D starting SGLT2i or GLP-1 RA, TriNetX; mean age 59.5 years; women 46.9% (SGLT2is) and 46.7% (GLP-1RAs)matched cohort
- Exposure
- SGLT2i vs GLP-1 RA in T2D
- Outcome
- Risk of rotator cuff tear and risk of rotator cuff repair surgery
Methodological detailstarget trial design, propensity score matched, TriNetX platform
- Target trial design
- Propensity score matched
- TriNetX platform
Main finding
As reported in the abstract
SGLT2is vs GLP-1RAsHazard ratio (95% CI)
Rotator cuff tear
0.812(0.761–0.867)
Rotator cuff repair surgery
0.900(0.815–0.994)
Observational data: associations, not effects.
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Risk of rotator cuff tear and rotator cuff repair surgery comparison between sodium-glucose cotransporter 2 inhibitors and glucagon like peptide-1 receptor agonists: A real-world study. Diabetes Metab. Published 8 February 2024. doi:10.
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