Risk factors for and risk of all-cause and atherosclerotic cardiovascular disease mortality in people with type 2 diabetes and peripheral artery disease: an observational, register-based cohort study
Main finding · All-cause mortality after onset of PADResult — go to the resultAdjusted hazard ratio 1.12 95% CI 1.05–1.19Authors' conclusion
The presence of T2D with concomitant PAD is related to an increased risk of both all-cause and cardiovascular mortality compared with individuals with only PAD. This argues for implementing optimized and intensive treatment strategies for individuals with both conditions.
Study context
- Population
- Persons with T2D in the Swedish National Diabetes Register (2005–2009) and matched controls without T2D, following onset of incident peripheral artery disease (PAD)
- Participants
- 150,215 vs 346,423
- Exposure
- T2D vs controls without T2D, after onset of incident PAD
- T2Dn = 150,215
- Controlsn = 346,423reference
- Outcome
- All-cause and atherosclerotic CVD mortality after onset of incident PAD
Methodological detailsobservational, controls matched for sex and age
- Observational
- Controls matched for sex and age
Main finding
All-cause mortality after onset of PAD
Adjusted hazard ratio
1.12
95% CI 1.05–1.19
P < 0.01
By group
T2D
600.4 per 10,000 person-years
CI 581.4–619.8
Controls
549.1 per 10,000 person-years
CI 532.1–566.5
T2Dvs Controls
adjusted HR 1.12 (95% CI 1.05–1.19); P < 0.01
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | Adjusted HR (95% CI) | P value | |
|---|---|---|---|
| Cardiovascular mortality after onset of PAD | 1.13 (1.07–1.19) | P < 0.01 | |
| 0.512Adjusted hazard ratio (log scale) |
Risk factors contributing to mortality prediction in T2D with PAD (gradient-boosting model)
- High age and hyperglycemia at baseline played a significant role in predictive models for all-cause and cardiovascular mortality
Original publication
Risk factors for and risk of all-cause and atherosclerotic cardiovascular disease mortality in people with type 2 diabetes and peripheral artery disease: an observational, register-based cohort study. Cardiovasc Diabetol. Published 15 April 2024. doi:10.
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