Risk Assessment for Gastrointestinal Diseases via Clinical Dimension and Genome-Wide Polygenic Risk Scores of Type 2 Diabetes: A Population-Based Cohort Study
Authors' conclusion
In this large cohort study, we found that T2D was associated with increased risks of a wide range of gastrointestinal outcomes. We suggest the importance of early detection and prevention of gastrointestinal disorders among patients with T2D.
Study context
- Population
- Participants free of gastrointestinal disorders at baseline, followed via linkage to multiple medical records
- Participants
- 374,125 participants
- Exposure
- T2D vs nondiabetes
- T2Dn = 19,719
- Outcome
- New onset of gastrointestinal diseases (15 GI diseases)
- Follow-up
- Median 12.0 years
Main finding
As reported in the abstract
Incident gastrointestinal diseases
T2D vs NondiabetesHazard ratio (95% CI)
Gastritis and duodenitis
1.58(1.51–1.65)
Peptic ulcer
1.56(1.43–1.71)
Diverticular disease
1.19(1.14–1.24)
Pancreatitis
1.45(1.24–1.71)
NAFLD
2.46(2.25–2.69)
Liver cirrhosis
2.92(2.58–3.30)
Biliary disease
1.18(1.10–1.26)
Gastrointestinal tract cancers
1.28(1.17–1.40)
Hepatobiliary and pancreatic cancer
2.32(2.01–2.67)
Observational data: associations, not effects.
Further findings
Polygenic risk scores (PRS) of T2D and clinical GI phenotypes
- Positive associations of PRS of T2D with gastritis, duodenitis and NAFLD
- Logistic models
Original publication
Risk Assessment for Gastrointestinal Diseases via Clinical Dimension and Genome-Wide Polygenic Risk Scores of Type 2 Diabetes: A Population-Based Cohort Study. Diabetes Care. Published 2 January 2024. doi:10.
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