Reversal of insulin resistance in people with obesity by lifestyle‐induced weight loss does not impact the proportion of circulating 12α‐hydroxylated bile acids
Authors' conclusion
Lifestyle-induced weight loss did improve glycaemic control but did not affect BA concentrations. Improvements in insulin sensitivity were not associated with changes in BA parameters in people with obesity, with or without T2D.
Study context
- Population
- People with obesity, with or without T2D, undergoing a lifestyle intervention
- Exposure
- Before vs after lifestyle-induced weight loss
- Outcome
- Ratio of 12α/non-12α-hydroxylated bile acids (BAs) in plasma
- Follow-up
- Before and after lifestyle intervention
Methodological detailstwo cohorts, before and after lifestyle intervention
- Two cohorts
- Before and after lifestyle intervention
Main finding
As reported in the abstract
Ratio of 12α/non-12α-hydroxylated BAs, change with intervention
- Obesity (OB): ratio unchanged (p = .178)
- T2D: ratio slightly increased upon intervention (p = .0147)
Observational data: associations, not effects.
Further findings
Glycaemic control and plasma BA concentrations
- Weight loss improved glycaemic control in both cohorts; plasma BA concentrations not affected
Plasma C4
- OB: unaffected (p = .20)
- T2D: significantly reduced after intervention (p = .0003)
Correlations of 12α/non-12α ratio with metabolic parameters
- No significant correlations with glucose, insulin or HOMA-IR, nor with plasma TG, LDL-C, lipoprotein (a) in the T2D cohort
Original publication
Reversal of insulin resistance in people with obesity by lifestyle‐induced weight loss does not impact the proportion of circulating 12α‐hydroxylated bile acids. Diabetes Obes Metab. Published 3 July 2024. doi:10.
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