Response to Surgery Assessments for Sparing Radioiodine Remnant Ablation in Intermediate-Risk Papillary Thyroid Cancer
Authors' conclusion
Through the 3-tiered assessments with response to surgery highlighted, postoperative ER and IDR spared from RAI remnant ablation may indicate similar favorable responses in intermediate-risk patients with PTC during 23.6 months of follow-up.
Study context
- Population
- Patients with intermediate-risk papillary thyroid cancer (PTC) and no evidence of disease after surgery, spared from radioiodine (RAI) thyroid remnant ablation after informed consent173 followed >12 months
- Participants
- 215 patients
- Exposure
- Excellent response (ER) vs indeterminate response (IDR) to surgery, both spared from RAI remnant ablation
- ERn = 102
- IDRn = 113reference
- Outcome
- No evidence of disease (NED) presenting as durable ER or IDR
- Follow-up
- Over 12 months
Methodological detailsactive surveillance, 3-tiered assessments
- Active surveillance
- 3-tiered assessments
Main finding
As reported in the abstract
NED rate · follow-up over 12 months
P = 0.20
Observational data: associations, not effects.
Further findings
Response category over time · median 23.6 (IQR 13.8-31.6) months
- ER share increased
- 82.8% (178/215)
- IDR share decreased
- 16.3% (35/215)
- Shifted from IDR to ER
- 85 patients
- Structural incomplete response
- 0.5% (1/215)
- Biochemical incomplete response
- 0.5% (1/215)
Successful remnant ablation without RAI (theranostic effect) among patients completing 2 diagnostic whole-body scans · median interval 13.0 months
- Successful remnant ablation
- 27.7% (26/94)
Original publication
Response to Surgery Assessments for Sparing Radioiodine Remnant Ablation in Intermediate-Risk Papillary Thyroid Cancer. J Clin Endocrinol Metab. Published 26 December 2022. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →