Resistance training enhances metabolic and muscular health and reduces systemic inflammation in middle-aged and older adults with type 2 diabetes: a meta-analysis
Authors' conclusion
Overall, resistance training provides consistent benefits for insulin sensitivity, muscle function, and systemic inflammation in middle-aged and older adults with T2DM
Study context
- Population
- Middle-aged and older adults (aged ≥50 years) with T2D; 55.8 % women; mean age 57.8 ± 8.4 years; mean BMI 30.9 ± 3.8 kg/m²
- Participants
- 2,012 participants43 RCTs
- Comparison
- Resistance training
- Outcome
- Markers of insulin resistance
Methodological detailsPubMed, Web of Science, Scopus and Cochrane CENTRAL searched from inception to May 20, 2025
- PubMed, Web of Science, Scopus and Cochrane CENTRAL searched from inception to May 20, 2025
Pooled result
As reported in the abstract
- Insulin
- MD −1.35 μIU/mL
- HOMA-IR
- MD −1.15
- Fasting glucose
- MD −6.99 mg/dL
- HbA1c
- MD −0.55 %
Further pooled results
| Outcome | Estimate |
|---|---|
| BMIModest reduction | MD −0.37 kg/m² |
| Muscle mass and strengthResistance training · muscle mass increased | MD 0.89 kg |
| Muscle mass and strengthResistance training · upper-body strength increased | SMD 2.28 |
| Muscle mass and strengthResistance training · lower-body strength increased | SMD 2.02 |
C-reactive protein (CRP)
- Significant reduction in CRP
- SMD −0.80
TNF-α and IL-6
- No significant changes in TNF-α or IL-6
Original publication
Resistance training enhances metabolic and muscular health and reduces systemic inflammation in middle-aged and older adults with type 2 diabetes: a meta-analysis. Diabetes Res Clin Pract. Published 15 October 2025. doi:10.
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