Residual β-Cell Function Is Associated With Longer Time in Range in Individuals With Type 1 Diabetes
Authors' conclusion
Significantly longer TIR, shorter TBR and TAR, and lower CV were observed in individuals with greater UCPCR-assessed β-cell function. Therefore, better CGM-derived metrics in individuals with preserved β-cell function may be a contributor to a lower risk of developing long-term complications.
Study context
- Population
- Individuals with T1D (64% female, age 41.0 ± 14.0 years; T1D duration 15.0 [IQR 6.0–29.0] years); Time in range (TIR) 66% (IQR 52–80%); Urinary C-peptide-to-creatinine ratio (UCPCR) 0.01 (IQR 0.00–0.41) nmol/mmol
- Participants
- 489 individuals
- Outcome
- Associations between residual β-cell function (UCPCR) and CGM metrics (TIR, TBR, TAR, glucose CV)
Methodological detailsContinuous Glucose Monitoring (CGM) devices: FreeStyle Libre 2 74.7%, Medtronic Guardian 13.8%, Dexcom G6 11.5%
- CGM devices: FreeStyle Libre 2 74.7%, Medtronic Guardian 13.8%, Dexcom G6 11.5%
Main finding
As reported in the abstract
Correlation of UCPCR with CGM metrics
- Detectable UCPCR (>0.01 nmol/mmol)
- 49.4%
- Higher UCPCR vs higher TIR
- r = 0.330, P < 0.05
- Higher UCPCR vs lower time below range (TBR)
- r = −0.237, P < 0.05
- Higher UCPCR vs lower time above range (TAR)
- r = −0.302, P < 0.05
- Higher UCPCR vs lower glucose coefficient of variance (CV)
- r = −0.356, P < 0.05
Observational data: associations, not effects.
Further findings
Correlation of UCPCR with HbA1c and total daily insulin dose
- UCPCR vs HbA1c
- r = −0.183, P < 0.05
- UCPCR vs total daily insulin dose
- r = −0.183, P < 0.05
Correlation of fasting glucagon/glucose ratio with TIR
- Glucagon/glucose ratio vs longer TIR
- r = 0.234, P < 0.05
Original publication
Residual β-Cell Function Is Associated With Longer Time in Range in Individuals With Type 1 Diabetes. Diabetes Care. Published 3 August 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →