Replication of association at the LPP and UBASH3A loci in a UK autoimmune Addison's disease cohort
Authors' conclusion
We confirm that variants at the LPP and UBASH3A loci confer susceptibility to AAD in a UK population.
Study context
- Population
- Patients with autoimmune Addison's disease (AAD) from across the UK, independent cohort
- Participants
- 420 AAD patients
- Comparison
- AAD cases vs controls
- Outcome
- Association of alleles with AAD
Methodological detailsreplication study
- Replication study
Main finding
As reported in the abstract
LPP allele association with AAD, OR
1.46 (1.21-1.75) (95% CI)
UBASH3A allele association with AAD, OR
1.40 (1.16-1.68) (95% CI)
Observational data: associations, not effects.
Further findings
- SH2B3 nominal association with AAD, OR
- 1.18 (1.02-1.35) (CI)
Original publication
Replication of association at the LPP and UBASH3A loci in a UK autoimmune Addison's disease cohort. Eur J Endocrinol. Published 11 January 2023. doi:10.
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