Lack of sensitivity of diagnostic Cushing-scores in Germany: a multicenter validation
Authors' conclusion
Both scores had limited sensitivity and high specificity in a German validation cohort. Further research is necessary to develop a screening score, which is effective in different healthcare systems and ethnicities.
Study context
- Population
- Patients in the multicentric German Cushing registry: 176 with confirmed Cushing's syndrome (CS) and 282 with suspected but finally excluded CS
- Participants
- 458 patients
- Comparison
- Spanish score vs Italian score for CS screening
- Outcome
- Proven CS not recommended for biochemical screening; patients without CS recommended for screening
Methodological detailsmulticentre, validation, prospective registry
- Multicentre
- Validation
- Prospective registry
Performance
As reported in the abstract
Pituitary CS not recommended
Adrenal CS not recommended
| Outcome | Spanish score | Italian score |
|---|---|---|
| Proven CS not recommended for screening | 17.5% | — not stated in the abstract |
| Without CS recommended for screening | 14% | About 12% |
| Proven CS in low-risk classes not recommended for screening | — not stated in the abstract | 29% |
— not stated in the abstract
Original publication
Lack of sensitivity of diagnostic Cushing-scores in Germany: a multicenter validation. Eur J Endocrinol. Published 10 January 2023. doi:10.
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