Renal function as an effect modifier of intensive glucose control in delaying cognitive function decline among individuals with type 2 diabetes: A revisit to the ACCORD MIND trial
Authors' conclusion
Our findings linked renal function with the benefits of intensive glucose control in delaying CFD, informing personalized HbA1c goals for those with diabetes and at risk of CFD.
Study context
- Population
- Participants with T2D from the ACCORD MIND trial; effect modifiers sought among 68 baseline variables
- Participants
- 2,977 participants
- Comparison
- Intensive vs standard glucose control
- Primary endpoint
- Cognitive function changes (digit symbol substitution test, Rey auditory verbal learning test, mini-mental state examination, Stroop test); effect size by Cohen's d
- Follow-up
- Baseline to 40th month
Methodological detailspost-hoc analysis, causal forest and causal tree algorithms
- Post-hoc analysis
- Causal forest and causal tree algorithms
Primary result
As reported in the abstract
Urinary albumin <0.4 mg/dl: slower cognitive function decline (CFD) with intensive control; Absolute function change (AFC) in mini-mental state examination (95% CI), Cohen's d
0.51 (0.04, 0.98), Cohen's d 0.25
eGFR 60–90 ml/min/1.73 m²: small benefit with intensive control; AFC in Stroop (95% CI), Cohen's d
1.28 (0.28, 2.27), Cohen's d 0.12
eGFR <60 ml/min/1.73 m²: faster CFD with intensive control; AFC in Rey auditory verbal learning test (95% CI), Cohen's d
−0.57 (−1.09, −0.05), Cohen's d −0.30
Age <60 years: benefit with intensive control; AFC in digit symbol substitution test (95% CI), Cohen's d
1.08 (0.06, 2.10), Cohen's d 0.13
Original publication
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