Relationship of serum 25-hydroxyvitamin D, obesity with new-onset obstructive sleep apnea
Main finding · New-onset OSA per SD increment in serum 25(OH)DResult — go to the resultHazard ratio 0.92 95% CI 0.89–0.95Authors' conclusion
There was an inverse relation of serum 25(OH)D with the risk of new-onset OSA in participants with both BMI ≥ 25 kg/m2 and WC ≥ 90 cm. Our findings suggest the importance of maintaining a higher serum 25(OH)D concentration for primary prevention of OSA in a population with obesity.
Study context
- Population
- UK Biobank participants without prior obstructive sleep apnea (OSA)UK Biobank
- Participants
- 444,975 participants
- Exposure
- Serum 25(OH)D concentration (per SD increment), with effect modification by BMI and waist circumference
- Outcome
- New-onset OSA
- Follow-up
- Median 12.0 years
Main finding
New-onset OSA per SD increment in serum 25(OH)D
Hazard ratio
0.92
95% CI 0.89–0.95
Per SD increment in serum 25(OH)D
HR 0.92 (95% CI 0.89–0.95)
Per SD increment in serum 25, as printed
As reported in the abstract
- New-onset OSA
- 6051 (1.4%)
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| New-onset OSA per SD increment in serum 25(OH)D, by BMI and WC categoriesBMI 25-30 kg/m² and WC ≥ 90 cm, per SD increment | 0.90 (0.84–0.95) | ||
| New-onset OSA per SD increment in serum 25(OH)D, by BMI and WC categoriesBMI ≥ 30 kg/m² and WC ≥ 90 cm, per SD increment | 0.85 (0.81–0.88) | P for interaction = 0.004 | |
| 0.512Hazard ratio (log scale) |
New-onset OSA per SD increment in serum 25(OH)D, by BMI and waist circumference (WC) categories
- No significant inverse association in the other four groups with BMI < 25 kg/m² or WC < 90 cm
Original publication
Relationship of serum 25-hydroxyvitamin D, obesity with new-onset obstructive sleep apnea. Int J Obes (Lond). Published 27 October 2023. doi:10.
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