Relationship of device measured physical activity type and posture with cardiometabolic health markers: pooled dose–response associations from the Prospective Physical Activity, Sitting and Sleep Consortium
Authors' conclusion
In this first activity type-specific analysis of device-based physical activity, ~64 min/day of walking and ~5.0 min/day of stair climbing were associated with a favourable cardiometabolic risk profile. The deleterious associations of sitting time were fully attenuated after exclusion of participants with prevalent CVD and medication use. Our findings on cardiometabolic health and durations of different activities of daily living and posture may guide future interventions involving lifestyle modification.
Study context
- Population
- Adults from six Prospective Physical Activity, Sitting and Sleep (ProPASS) cohorts with thigh-worn accelerometry; mean ± SD age 54.5±9.6 years; 54.8% female
- Participants
- 12,095 adults6 cohorts
- Comparison
- Daily durations of walking, stair climbing, running, standing and sitting
- Outcome
- Composite cardiometabolic health score (standardised z scores)
Methodological detailscross-sectional, pooled dose–response, thigh-worn accelerometry, six cohorts, ProPASS Consortium
- Cross-sectional
- Pooled dose–response
- Thigh-worn accelerometry
- Six cohorts
- ProPASS Consortium
Pooled result
As reported in the abstract
≈64 min/day walking, z score
−0.14 [−0.25, −0.02] (95% CI)
5 min/day stair climbing, z score
−0.14 [−0.24, −0.03] (95% CI)
Equivalent magnitude of association at standing
2.6 h/day
Inverse dose-response for sitting time, markedly less favourable above
12.1 h/day
Further pooled results
Sitting time, sensitivity analysis excluding prevalent CVD or medication use
- Associations for sitting time no longer significant
Individual cardiometabolic markers (BMI, waist circumference, TG, HDL-C, HbA1c, total cholesterol)
- Dose-response pattern generally consistent with composite score across activity and posture types
Original publication
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