Relationship between trajectory of Chinese visceral adiposity index and risk of type 2 diabetes mellitus: Evidence from the China ‐ PAR project
Authors' conclusion
Initially high and persistently elevated CVAI is significantly associated with an increased risk of T2DM, with a particular focus on women, younger people, nonsmokers and physically inactive individuals. Continuous monitoring of CVAI levels will benefit effective identification, early intervention and management of individuals at high risk of T2DM.
Study context
- Population
- Participants of the China-PAR prospective project; Chinese visceral adiposity index (CVAI) calculated from age, BMI, waist circumference, TG and HDL-CChina-PAR
- Participants
- 52,394 participants
- Exposure
- CVAI trajectory patterns vs low-increasing CVAI
- Outcome
- Risk of T2DM by CVAI trajectory pattern
Methodological detailslatent mixture modelling of trajectories, logistic regression
- Latent mixture modelling of trajectories
- Logistic regression
Main finding
As reported in the abstract
T2DM
Each group vs low-increasingOdds ratio (95% CI)
Moderate-increasing
1.73(1.49–2.00)
Moderate high-increasing
3.48(3.01–4.03)
High-increasing
5.50(4.67–6.47)
Observational data: associations, not effects.
Further findings
| Outcome | OR (95% CI) | |
|---|---|---|
| T2DM, womenModerate-increasingvs Low-increasing | 3.28 (2.56–4.19) | |
| T2DM, womenModerate high-increasingvs Low-increasing | 7.85 (6.09–10.13) | |
| T2DM, womenHigh-increasingvs Low-increasing | 13.21 (9.98–17.49) | |
| T2DM, menModerate-increasingvs Low-increasing | 1.20 (0.99–1.45) | |
| T2DM, menModerate high-increasingvs Low-increasing | 2.18 (1.82–2.62) | |
| T2DM, menHigh-increasingvs Low-increasing | 3.60 (2.93–4.43) | |
| 0.050.21520Odds ratio (log scale) |
Effect modification of CVAI trajectory–T2DM association
- Significant effect modification by age, smoking and physical activity
- all Pinteraction <0.05
Original publication
Relationship between trajectory of Chinese visceral adiposity index and risk of type 2 diabetes mellitus: Evidence from the China ‐ PAR project. Diabetes Obes Metab. Published 19 November 2024. doi:10.
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