Sex differences in ectopic lipid deposits and cardiac function across a wide range of glycemic control: a secondary analysis
Authors' conclusion
Sex differences in HCL and MYCL may be associated with a higher cardiovascular disease risk observed in female individuals progressing to diabetes. Further studies are needed to elucidate possible sex differences with advancing glucometabolic impairment and obesity and their potential impact on cardiovascular outcomes.
Study context
- Population
- Individuals with normoglycemia, prediabetes or T2D across BMI strata, from 17 clinical experimental studies
- Participants
- 503 individuals17 studies
- Comparison
- Female vs male individuals across glycemic categories and BMI strata
- Primary endpoint
- Sex differences in intrahepatocellular lipids (HCL), intramyocardial lipids (MYCL) and cardiac function
Methodological detailspooled individual-level data, 3T and 7T magnetic resonance spectroscopy, cardiac MRI (ECG-gated TrueFISP), three-way ANCOVA with post hoc simple effects analyses
- Pooled individual-level data
- 3T and 7T magnetic resonance spectroscopy
- Cardiac MRI (ECG-gated TrueFISP)
- Three-way ANCOVA with post hoc simple effects analyses
Primary result
As reported in the abstract
Sex differences in HCL, MYCL and cardiac function
- HCL increased consistently with BMI and worsening glucose metabolism, especially in females
- MYCL increased with BMI and glucose impairment in females, not in males
- Cardiac function loss differed by sex, with significant effects in males with worsening glucose metabolism
- Myocardial mass and ventricular volume higher in males in all groups; difference narrowed with increasing BMI and progressing dysglycemia
Original publication
Sex differences in ectopic lipid deposits and cardiac function across a wide range of glycemic control: a secondary analysis. Obesity (Silver Spring). Published 18 November 2024. doi:10.
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