Relationship between the magnitude of body mass index reductions and remission in patients with type 2 diabetes in real world settings: Analysis of nationwide patient registry in Japan ( JDDM 74)
Authors' conclusion
Modest weight losses of 3.0-7.9% were significantly associated with remission, but a minimum of 10% weight loss would be required in addition to an early diagnosis to achieve a 10% remission rate in clinical settings. Our results implied that remission may be expected with a relatively lower BMI in an Asian population compared with that was reported in Western populations if accompanied by weight loss.
Study context
- Population
- Japanese patients with T2D aged ≥18 years with HbA1c ≥6.5% and/or glucose-lowering drug prescription, specialists' clinics, from 1989 followed until September 2022
- Participants
- 39,676 patients
- Exposure
- Categories of 1-year weight change
- Outcome
- Remission: maintaining HbA1c <6.5% at least 3 months after cessation of a glucose-lowering drug
Methodological detailsnationwide patient registry, specialists' clinics, logistic regression analysis
- Nationwide patient registry
- Specialists' clinics
- Logistic regression analysis
Main finding
As reported in the abstract
Remission
Remissions during the study period
3454
Observational data: associations, not effects.
Further findings
About, per 1000 person-years
| Outcome | 7.0-9.9% reduction | ≥10% reduction |
|---|---|---|
| Remission per 1000 person-years, baseline BMI ≥22.5 · 1 year | 25 | 50 |
Remission per 1000 person-years with 10% body mass index (BMI) reduction, by subgroup
- Baseline HbA1c 6.5-6.9 and 10% BMI reduction
- 99.2
- Not taking glucose-lowering drugs and 10% BMI reduction
- 91.8
Original publication
Relationship between the magnitude of body mass index reductions and remission in patients with type 2 diabetes in real world settings: Analysis of nationwide patient registry in Japan ( JDDM 74). Diabetes Obes Metab. Published 7 July 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →