Incidence and predictors of remission and relapse of type 2 diabetes mellitus in Japan: Analysis of a nationwide patient registry (JDDM73)
Authors' conclusion
The results showed that the incidence of remission and predictors of relapse, especially baseline BMI, might differ greatly between East Asian and Western populations. Furthermore, the relationships of BMI reduction with remission and relapse may be greater in East Asian than in Western populations, implying ethnic differences in returning from overt hyperglycaemia to nearly normal glucose levels.
Study context
- Population
- Japanese patients with T2D aged ≥18 years, HbA1c ≥48 mmol/mol (6.5%) and/or glucose-lowering drug prescription, specialist clinic databases from 1989, followed until September 2022
- Participants
- 48,320 patients
- Outcome
- Incidence of remission (HbA1c <48 mmol/mol at least 3 months after cessation of glucose-lowering drug) and 1-year relapse (failure to maintain remission for 1 year)
Methodological detailsnationwide patient registry, specialist clinics
- Nationwide patient registry
- Specialist clinics
Main finding
As reported in the abstract
Overall incidence of remission per 1000 person-years
10.5
Incidence of remission per 1000 person-years, HbA1c 48 to 53 mmol/mol (6.5% to 6.9%)
27.8
Incidence of remission per 1000 person-years, no glucose-lowering drugs at baseline
21.7
Incidence of remission per 1000 person-years, ≥10% body mass index (BMI) reduction in 1 year
48.2
Observational data: associations, not effects.
Further findings
Relapse within 1 year among persons with remission
- Persons with remission
- 3677
- Relapsed within 1 year (approximately two-thirds)
- 2490
- Longer duration, lower BMI at baseline and lower BMI reduction at 1 year significantly associated with relapse
Original publication
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