Relationship between glycemic variability and the incidence of postoperative atrial fibrillation following cardiac Surgery: A retrospective study from MIMIC-IV database
Authors' conclusion
Increased GV is associated with higher incidence of POAF.
Study context
- Population
- Patients undergoing cardiac surgery; median age 68.3 years, 25.5 % female
- Participants
- 5,365 patients
- Exposure
- Moderate and high vs low glycaemic variability tertiles
- Outcome
- Incidence of POAF
Methodological detailsMIMIC-IV database
- MIMIC-IV database
Main finding
As reported in the abstract
POAF
Each group vs low GVOdds ratio (95 % CI)
Moderate GV
1.82(1.49–2.22)
High GV
2.25(1.80–2.82)
Observational data: associations, not effects.
Further findings
New-onset postoperative atrial fibrillation (POAF), overall
- Patients with new-onset POAF
- 1056 (19.7 %)
Prediction of POAF by glycemic variability (GV)
- AUC of GV
- 0.77 (95 % CI 0.76-0.79)
Dose-response between GV and POAF
- Threshold-based nonlinear relationship: POAF likelihood rises with GV when GV < 24 %; no significant further effect when GV ≥ 24 %
Original publication
Relationship between glycemic variability and the incidence of postoperative atrial fibrillation following cardiac Surgery: A retrospective study from MIMIC-IV database. Diabetes Res Clin Pract. Published 28 December 2024. doi:10.
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