Ceramide‐based risk score CERT‐1 improves risk prediction for overall mortality and adverse cardiovascular outcomes in patients with and without cardiovascular disease: A prospective cohort study
Authors' conclusion
The ceramide-based risk score CERT1 risk score improves risk prediction for long-term risk of overall mortality and adverse cardiovascular outcomes in patients with and without CVD.
Study context
- Population
- 334 patients with established/suspected cardiovascular disease (CVD) and 196 patients with T2Dtwo cohorts
- Exposure
- CERT1 risk categories
- Outcome
- Composite of:
- Overall mortality
- Incident nonfatal CVD outcomes (MI, ischaemic stroke or permanent AF)
- Follow-up
- Median 74 months (IQR 54-79 months)
Methodological detailstwo cohorts combined
- Two cohorts combined
Main finding
As reported in the abstract
Primary composite outcome
Each group vs low riskAdjusted hazard ratio (95% CI)P value
High risk
2.43(1.39–4.22)
P = 0.002Increased risk
2.16(1.28–3.63)
P = 0.004- Patients developing the primary composite outcome (72 nonfatal CVD outcomes, 67 total deaths)
- 139
Observational data: associations, not effects.
Further findings
Discrimination (AUROC) for primary composite outcome: CERT1 added to traditional CVD risk factors and pre-existing CVD
- Adding CERT1 risk score improved the discriminatory capability of the model
- P = 0.0275
Original publication
Ceramide‐based risk score CERT‐1 improves risk prediction for overall mortality and adverse cardiovascular outcomes in patients with and without cardiovascular disease: A prospective cohort study. Diabetes Obes Metab. Published 26 December 2024. doi:10.
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