Human cardiac tissues produce lower contractile stress and exhibit slower cross-bridge cycling in type 2 diabetes
Authors' conclusion
Our key results point to potential mechanisms of clinical dysfunction in diabetic heart tissue. Lower active force production in diabetic trabeculae suggests that these patients are developing contractile dysfunction. Furthermore, slower cross-bridges can contribute to diastolic dysfunction, especially at higher heart rates, by prolonging cardiac relaxation.
Study context
- Population
- Non-diabetic and T2D patients without HF; permeabilised atrial trabeculae
- Comparison
- T2D vs non-diabetic atrial trabeculae
- Outcome
- Cross-bridge function
Methodological detailsex vivo permeabilised atrial trabeculae
- Ex vivo permeabilised atrial trabeculae
Main finding
As reported in the abstract
Active stress lower in diabetic trabeculae (on average)
20%
Cross-bridge stiffness lower in diabetic trabeculae (on average)
16%
Reduction in characteristic frequencies in diabetic trabeculae, reflecting slower cross-bridge cycling
24%
Original publication
Human cardiac tissues produce lower contractile stress and exhibit slower cross-bridge cycling in type 2 diabetes. Cardiovasc Diabetol. Published 3 July 2025. doi:10.
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