Reduced muscle strength (dynapenia) in women with obesity confers a greater risk of falls and fractures in the UK Biobank
Authors' conclusion
Dynapenia further increases the increased risk of leg and ankle fractures in obesity and counteracts the protective effects of obesity on fracture risk at all other sites (wrist, arm, hip, spine, other bones).
Study context
- Population
- Women aged 60–82 years, UK Biobank
- Participants
- 16,147 women
- Exposure
- Obesity and dynapenia vs normal weight and normal handgrip strength (HGS)
- Outcome
- Self-reported falls (previous 12 months), lower extremity fractures and all other fractures (previous 5 years)
Methodological detailsUK Biobank, multiple logistic regression
- UK Biobank
- Multiple logistic regression
Main finding
As reported in the abstract
Lower extremity fracture risk · previous 5 years
Each group vs normal weightOdds ratio (95% CI)
Obesityindependent of areal BMD
1.25(1.12–1.38)
Dynapeniaindependent of areal BMD; reported as associated with greater risk
0.87(0.77–0.98)
Observational data: associations, not effects.
Further findings
| Outcome | OR (95% CI) | |
|---|---|---|
| All other fracture sites · previous 5 yearsObesityvs Normal weightProtective | 0.77 (0.61–0.96) | |
| All other fracture sites · previous 5 yearsObesity with low HGSvs Normal weightEquivalent fracture risk | 1.06 (0.82–1.38) | |
| 0.512Odds ratio (log scale) |
Falls · previous 12 months
- Women who fell
- 3793/16,147
Fall-related fractures
- Eligible women with fall-related fractures
- 1413/15,570 (9.1%)
Original publication
Reduced muscle strength (dynapenia) in women with obesity confers a greater risk of falls and fractures in the UK Biobank. Obesity (Silver Spring). Published 11 December 2022. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →