Body surface area is a potential obesity index: Its genetic determination and its causality for later‐life diseases
Authors' conclusion
These findings increase understanding of genetic determinants for BSA and its relationship with complex traits and diseases, and BSA could be regarded as a potential obesity trait.
Study context
- Population
- European individuals in the UK Biobankmore than
- Participants
- 330,000 individuals
- Outcome
- Genetic factors contributing to BSA
Methodological detailslarge-scale, Mendelian randomization, genetic correlation analysis, enrichment analysis
- Large-scale
- Mendelian randomization
- Genetic correlation analysis
- Enrichment analysis
Main finding
As reported in the abstract
Genetic loci for BSA
- Conditionally independent SNPs identified, mapping to genes regulating adipogenesis and metabolism, enriched in adipogenesis-related pathways
- 456
Further findings
Genetic correlation of body surface area (BSA) with obesity phenotypes and anthropometry
- BSA highly genetically correlated with obesity phenotypes; all studied UK Biobank anthropometry parameters significantly positively associated with BSA
Association of BSA with chronic diseases
- Chronic diseases phenotypically associated with BSA
- 13
- Diseases genetically associated with BSA
- 6
Mendelian randomization
- BSA has a causal effect in increasing the risk of some diseases
Original publication
Body surface area is a potential obesity index: Its genetic determination and its causality for later‐life diseases. Obesity (Silver Spring). Published 10 December 2022. doi:10.
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