FSTL3 is highly expressed in adipose tissue of individuals with overweight or obesity and is associated with inflammation
Authors' conclusion
FSTL3 was highly expressed in adipose tissue in individuals with overweight or obesity and could suppress adipocyte inflammation. Serum FSTL3 levels might be considered as a biomarker of visceral obesity and inflammation.
Study context
- Population
- Individuals aged 18–67 years with or without overweight or obesity; subcutaneous and visceral adipose tissue and serum FSTL3
- Participants
- 236 individuals
- Comparison
- Overweight or obesity vs normal weight
- Overweight or obesityn = 171
- Outcome
- Adipose FSTL3 expression and function
Methodological detailscross-sectional, bulk transcriptome sequencing, in vitro human adipocyte experiments
- Cross-sectional
- Bulk transcriptome sequencing
- In vitro human adipocyte experiments
Main finding
As reported in the abstract
- Adipose FSTL3 expression higher in overweight or obesity than normal weight
- FSTL3 mainly expressed in mature adipocytes and stimulated by TNFα
- FSTL3 suppressed inflammatory responses in human adipocytes; FSTL3 knockdown promoted them
Further findings
Serum FSTL3 correlations
- Serum FSTL3 correlated with adipose FSTL3 expression and obesity-related indicators
- all p < 0.05
- Serum FSTL3 independently associated with visceral fat area and serum TNFα (multiple linear regression)
- both p < 0.05
Original publication
FSTL3 is highly expressed in adipose tissue of individuals with overweight or obesity and is associated with inflammation. Obesity (Silver Spring). Published 10 December 2022. doi:10.
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