Reduced insulin clearance in paediatric metabolic (dysfunction)‐associated fatty liver disease and its dual role in beta‐cell offload and diabetes risk
Authors' conclusion
A lower HIC may offload pancreatic β-cells at an early stage. However, obese children with MAFLD are at risk of developing diabetes, and preventive efforts should be prioritized.
Study context
- Population
- Obese Chinese children aged 4–17 years74 MAFLD
- Participants
- 204 children
- Exposure
- Obese children with MAFLD vs obese children without liver involvement
- MAFLDn = 74
- Outcome
- Correlation between HIC, insulin sensitivity and β-cell function (OGTT-derived)
Methodological detailshigh-fat diet mouse model
- High-fat diet mouse model
Main finding
As reported in the abstract
HIC, insulin resistance and β-cell function, MAFLD vs without liver involvement
Hepatic insulin clearance (HIC) vs insulin sensitivity, r
−0.5035
p < 0.0001
HIC vs β-cell function, r
−0.4576
p < 0.0001
Observational data: associations, not effects.
Further findings
Children with MAFLD in prediabetes
- Pancreatic β-cell dysfunction
- P = 0.046
- Accompanied by future reduced HIC
- P = 0.034
High-fat diet mouse model: insulin-degrading enzyme expression
- Reduction in insulin-degrading enzyme expression in MAFLD mice, consistent with decreased HIC
- 50%
Original publication
Reduced insulin clearance in paediatric metabolic (dysfunction)‐associated fatty liver disease and its dual role in beta‐cell offload and diabetes risk. Diabetes Obes Metab. Published 27 August 2024. doi:10.
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