Paediatric Virilizing Ovarian Tumors: A Systematic Review
Authors' conclusion
Hyperandrogenic manifestations are less frequent in children < 8 years with VOT. Elevated 17-OHP and/or DHEAS should not exclude the possibility of VOT. Etiological spectrum of paediatric VOT is relatively age-specific. Larger multicenter studies with longer follow-up are warranted to better delineate prognosis and management strategies.
Study context
- Population
- Paediatric (<20 years) patients with virilizing ovarian tumors (VOT), with biochemical hyperandrogenemia and histologically confirmed ovarian neoplasm; English-language reports from PubMed and Google Scholarmedian age 15 years
- Participants
- 117 participants
- Outcome
- Characteristics of paediatric VOT
Methodological detailsPRISMA guidelines
- PRISMA guidelines
Pooled result
As reported in the abstract
- Hirsutism
- 73.5%
- Clitoromegaly
- 68.4%
- Menstrual irregularity
- n = 79
- Voice change
- 60.7%
- Elevated baseline 17-OHP
- 70%
- Elevated baseline dehydroepiandrosteroe sulfate (DHEAS)
- 18.3%
- Median tumor size
- 6.6 cm
- Bilateral tumors
- 8 patients
Original publication
Paediatric Virilizing Ovarian Tumors: A Systematic Review. Clin Endocrinol (Oxf). Published 3 December 2025. doi:10.
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