Red blood cell distribution width to albumin ratio as a predictor of all-cause and cardiovascular mortality in patients with cardiovascular disease with diabetes or pre-diabetes: National Health and Nutrition Examination Survey 2001–2018
Main finding · All-cause mortalityResult — go to the resultHazard ratio 2.73 95% CI 2.19–3.41Authors' conclusion
Elevated RAR index is associated with higher all-cause and cardiovascular mortality in patients with CVD with diabetes or pre-diabetes.
Study context
- Population
- Patients with Cardiovascular Disease (CVD) with diabetes or pre-diabetes, NHANES 2001–2018
- Participants
- 2,952 patients
- Exposure
- RAR index Q4 vs Q1
- Outcome
- All-cause and cardiovascular mortality (National Death Index)
Methodological detailsNHANES 2001–2018, weighted Cox proportional hazards model, restricted cubic splines
- NHANES 2001–2018
- Weighted Cox proportional hazards model
- Restricted cubic splines
Main finding
All-cause mortality
Hazard ratio
2.73
95% CI 2.19–3.41
Q4vs Q1
HR 2.73 (95% CI 2.19–3.41)
As reported in the abstract
- Deaths overall
- 1225 (41.5 %)
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | |
|---|---|---|
| Cardiovascular mortality | 3.05 (2.33–4.01) | |
| 0.20.5125Hazard ratio (log scale) |
- Cardiovascular mortality — CVD deaths
- 489 (16.57%)
Subgroups and dose-response
- Results uniform across all subgroups
- Restricted cubic splines (RCS): positive correlation between RAR index and all mortality types
Original publication
Red blood cell distribution width to albumin ratio as a predictor of all-cause and cardiovascular mortality in patients with cardiovascular disease with diabetes or pre-diabetes: National Health and Nutrition Examination Survey 2001–2018. Diabetes Res Clin Pract. Published 4 June 2025. doi:10.
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