Intellectual developmental disability and all-cause and cause-specific mortality among individuals with type 2 diabetes mellitus
Main finding · All-cause mortalityResult — go to the resultHazard ratio 3.40 95 % CI 3.14–3.68Authors' conclusion
Individuals with T2DM and IDD, particularly those with severe IDD, have a significantly higher mortality risk. Tailored healthcare strategies and enhanced social support are urgently required to reduce disparities in this vulnerable population.
Study context
- Population
- Individuals with T2D who underwent health screenings through the Korea National Health Insurance Service 2015–20160.22 % with IDD
- Participants
- 2,522,244 individuals
- Exposure
- IDD vs no IDD in T2D
- IDDn = 5,627
- Outcome
- All-cause mortality
- Follow-up
- Six-year median
Methodological detailsnationwide, multivariable Cox proportional hazards models
- Nationwide
- Multivariable Cox proportional hazards models
Main finding
As reported in the abstract
Hazard ratio
3.40
95 % CI 3.14–3.68
IDDvs No IDD
HR 3.40 (95 % CI 3.14–3.68)
- Deaths in total population
- 201,153 (7.98 %)
- Greater IDD severity correlated with higher risk
- P < 0.001
Observational data: associations, not effects.
Further findings
Cardiovascular mortality
- Cardiovascular mortality risk significantly elevated, HR
- 3.77 (3.12-4.55) (95% CI)
Cancer mortality
- Cancer mortality risk significantly elevated, HR
- 1.52 (1.24-1.86) (95% CI)
Respiratory disease mortality
- Respiratory disease mortality risk significantly elevated, HR
- 7.71 (6.27-9.48) (95% CI)
All-cause mortality by IDD severity
- Greater IDD severity correlated with higher all-cause mortality risk
- P < 0.001
All-cause mortality by age
- Younger individuals showed stronger associations
Original publication
Intellectual developmental disability and all-cause and cause-specific mortality among individuals with type 2 diabetes mellitus. Diabetes Res Clin Pract. Published 3 June 2025. doi:10.
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