Haemoglobin glycation index and in‐hospital mortality after acute myocardial infarction in patients with/without diabetes: A prospective, nationwide and multicentre registry
Authors' conclusion
This study revealed an L-shaped association between HGI and in-hospital mortality in AMI patients with T2DM, with an inflection point of HGI at 0.69%. In contrast, a linear negative association was observed in AMI patients without T2DM.
Study context
- Population
- Patients with acute myocardial infarction (AMI), with or without T2D; Haemoglobin glycation index (HGI) = measured haemoglobin A1c (HbA1c) minus HbA1c predicted from fasting plasma glucose (FPG) (HbA1c = 0.272 × FPG(mmol/L) + 4.302)
- Participants
- 5,308 patients
- Exposure
- Low and high HGI vs moderate HGI, in patients with and without T2D
- Outcome
- In-hospital mortality
- Follow-up
- Hospitalization
Methodological detailsnationwide
- Nationwide
Main finding
As reported in the abstract
Increased risk (fold), diabetic
2.781
multivariable logistic regression; T2D population
Increased risk (fold), nondiabetic
2.830
multivariable logistic regression; non-T2D population
- Died during hospitalization, diabetic patients
- 94 (4.5%)
- Died during hospitalization, nondiabetic patients
- 131 (4.1%)
Observational data: associations, not effects.
Original publication
Haemoglobin glycation index and in‐hospital mortality after acute myocardial infarction in patients with/without diabetes: A prospective, nationwide and multicentre registry. Diabetes Obes Metab. Published 3 June 2025. doi:10.
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