Additive effect of atherogenic index of plasma and social determinants of health on all-cause and cardiovascular mortality in U.S. adults with diabetes and prediabetes
Authors' conclusion
The AIP + SDoH combination is a robust independent prognostic factor, highlighting its potential to improve mortality prediction in U.S. adults with diabetes and prediabetes.
Study context
- Population
- U.S. adults with diabetes and prediabetes, NHANES 2005–2018
- Participants
- 6,180 adults
- Exposure
- Atherogenic index of plasma (AIP), Social Determinants of Health (SDoH) and their combination as predictors of mortality
- Outcome
- All-cause and cardiovascular mortality
Methodological detailsPredictive performance of SDoH and 8 metabolic health-related indicators assessed by ROC curves; associations analysed by Kaplan-Meier curves and Cox proportional hazards regression
- Predictive performance of SDoH and 8 metabolic health-related indicators assessed by ROC curves; associations analysed by Kaplan-Meier curves and Cox proportional hazards regression
Main finding
As reported in the abstract
- AIP was the most efficacious metabolic health-related predictor
- AIP + SDoH combination had an additive effect, significantly predicting both all-cause and CV mortality (Cox regression and subgroup analyses)
Observational data: associations, not effects.
Original publication
Additive effect of atherogenic index of plasma and social determinants of health on all-cause and cardiovascular mortality in U.S. adults with diabetes and prediabetes. Diabetes Res Clin Pract. Published 3 June 2025. doi:10.
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