Diabetes Progression and Its Impact on Kidney Cancer Risk: Insights From a Longitudinal Korean Cohort Study
Authors' conclusion
Diabetes progression is strongly associated with an increased risk of kidney cancer. These findings underscore the importance of targeted screening and awareness programs for kidney cancer in individuals with advanced diabetes.
Study context
- Population
- Patients with T2D who underwent health examinations in 2015 and 2016, National Health Information Database, South Korea; excluding pre-existing cancer or death within a year; progression score (0–6) from number of oral glucose-lowering drugs (GLDs), diabetes duration, insulin use, chronic kidney disease (CKD), diabetic retinopathy (DR) or CVD
- Participants
- 2,365,294 patients
- Exposure
- Diabetes progression scores 1, 2, 3 and ≥4 vs score 0
- Outcome
- Incident kidney cancer (ICD-10 C64)
- Follow-up
- Until 2022
Methodological detailsnationwide, longitudinal
- Nationwide
- Longitudinal
Main finding
As reported in the abstract
Kidney cancer
Each group vs score 0Adjusted hazard ratio (95% CI)
Score 1
1.21(1.13–1.30)
Score 2
1.28(1.18–1.38)
Score 3
1.37(1.23–1.51)
Score ≥4
1.73(1.49–2.01)
Observational data: associations, not effects.
Further findings
Individual indicators of diabetes progression
- Prolonged diabetes duration and presence of CKD or DR linked to higher hazard ratios (HRs) for kidney cancer
Original publication
Diabetes Progression and Its Impact on Kidney Cancer Risk: Insights From a Longitudinal Korean Cohort Study. J Clin Endocrinol Metab. Published 3 June 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →