Diabetes progression and its association with fracture risk in type 2 diabetes
Authors' conclusion
The risk of fractures increased incrementally in parallel with diabetes progression, most notably for hip fractures.
Study context
- Population
- Patients with T2DM from the Korean National Health Information Database who underwent health examinations in 2015–2016; prior fractures or death within one year excluded
- Participants
- 2,069,920 patients
- Exposure
- Diabetes progression score categories
- Outcome
- Incident fractures (ICD-10 codes), tracked until 2023
Methodological detailsnationwide database (Korean National Health Information Database)
- Nationwide database (Korean National Health Information Database)
Main finding
As reported in the abstract
Fracture risk by diabetes progression score · median follow-up 6.4 years
Hazard ratio (95% CI)
Score 4
1.60(1.56–1.64)
Score 5
1.87(1.78–1.96)
- Fractures occurred
- 169,595
- Vertebral fractures
- 69,723
- Hip fractures
- 23,581
Observational data: associations, not effects.
Further findings
Fracture risk by individual progression component
| HR (95% CI) | ||
|---|---|---|
| Insulin use | 1.40 (1.38–1.42) | |
| CVD | 1.26 (1.24–1.28) | |
| 0.512Hazard ratio (log scale) |
- Fracture risk by individual progression component — Each component independently associated with fracture risk (HRs ranging)
- 1.14 to 1.40
Hip fractures
- The magnitude of increase was more pronounced for hip fractures
Original publication
Diabetes progression and its association with fracture risk in type 2 diabetes. Osteoporos Int. Published 20 May 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →