Osteoporosis, bone & mineral

Intellectual disabilities and risk of fractures: A population-based cohort study

Osteoporos IntPublished Retrospective cohort study

Authors' conclusion

Individuals with ID are at an increased risk of any fractures, vertebral fractures, and hip fractures compared to those without ID.

Study context

Population
Individuals who underwent Korean national health examinations in 2009 (Korean National Disability Registry and National Health Insurance Service data), followed until 2020mean follow-up 10.0 years
Participants
3,815,545 individuals
Exposure
Intellectual disabilities vs no intellectual disabilities
  • Intellectual disabilities (ID)n = 3,582
Outcome
Any fractures, vertebral fractures and hip fractures
Methodological detailspopulation-based, multivariable-adjusted Cox proportional hazards
  • Population-based
  • Multivariable-adjusted Cox proportional hazards

Main finding

As reported in the abstract

mean follow-up 10.0 years
ID vs Without IDEstimate (95% CI)
207 cases among ID
aHR (any fractures) 1.69(1.47–1.94)
47 cases among ID
aHR (vertebral fractures) 2.07(1.55–2.75)
27 cases among ID
aHR (hip fractures) 3.01(2.07–4.39)

Observational data: associations, not effects.

Further findings

Fracture risk by age (subgroup)

ID aged 20-39 years had higher risk of fractures than older age groups

Original publication

Intellectual disabilities and risk of fractures: A population-based cohort study. Osteoporos Int. Published 13 May 2025. doi:10.1007/s00198-025-07519-9

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