Reading Hormones Through The Failing Kidney: Pitfalls in Endocrine Test Interpretation in Chronic Kidney Disease
Authors' conclusion
We conclude with a practical approach that includes shared decision-making and research priorities for CKD-specific reference intervals.
Study context
- Population
- Adults with chronic kidney disease (CKD) stages G3-G5
- Outcome
- Effects of CKD on endocrine tests
Methodological detailstest-centered approach
- Test-centered approach
Main finding
As reported in the abstract
- For each test, the dominant mechanism (reduced renal clearance, altered binding proteins, genuine axis dysregulation, analytical interference, or treatment effects) and the tests that remain reliable are identified
Further findings
Key recommendations
- Pairing glycated hemoglobin (HbA1c) with continuous glucose monitoring in advanced CKD
- Assessing thyroid function before dialysis and heparin
- Applying CKD stage-specific cut-offs to the dexamethasone suppression test
- Relying on renin suppression when screening for primary aldosteronism
- Avoiding urinary free cortisol and urinary metanephrines
- Interpreting parathyroid hormone (PTH) as a trend using a single assay
- Using non-renally cleared bone turnover markers
Original publication
Reading Hormones Through The Failing Kidney: Pitfalls in Endocrine Test Interpretation in Chronic Kidney Disease. Endocr Pract. Published 12 November 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →