Rapid and long-lasting remodelling of the blood transcriptome following bariatric surgery
Authors' conclusion
Taken together, we show that previously unreported early changes in blood gene expression after bariatric surgery provide in-depth insights into the resolution of the chronic inflammation associated with severe obesity and its connection with metabolic improvement.
Study context
- Population
- Patients undergoing bariatric surgery for severe obesity, 'Personalised Medicine for Morbid Obesity' cohort; blood samples
- Outcome
- Early blood gene expression changes after bariatric surgery
- Follow-up
- A few days after surgery
Main finding
As reported in the abstract
- Widespread changes in gene expression only a few days after surgery
- Immune response pathways affected: decreased expression of the NF-κB pathway and neutrophil cytotoxic activity genes, suggesting reduced obesity-associated inflammation
- Metabolic signalling affected: decreased expression of genes of glucagon and insulin secretion pathways and of key regulators such as ghrelin
Further findings
Comparison with public transcriptomics datasets
- Transcriptome-wide reversal of expression changes associated with obesity and with obesity-related forms of T2D
Persistence of early changes (comparison with longer-term follow-up studies) · several months
- A large fraction of early-induced expression changes likely persist for several months
Original publication
Rapid and long-lasting remodelling of the blood transcriptome following bariatric surgery. Int J Obes (Lond). Published 19 August 2026. doi:10.
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