Randomized controlled trial of time-restricted eating: secondary analyses of breath acetone
Primary result · Breath acetoneResult — go to the resultBetween group difference 5.45 parts per millionAuthors' conclusion
We show for the first time that ketone bodies decrease after a period of adaptation to time-restricted eating of a calorie-restricted diet likely from enhanced fat oxidation and ketone utilization.
Study context
- Population
- Subjects on an 8-week calorie-restricted diet randomized to different time-restricted eating windows
- Participants
- 60 subjects
- Comparison
- 14-hour fast, 10-hour eating window (14:10) vs 12-hour fast, 12-hour eating window (12:12) on a calorie-restricted diet
- Primary endpoint
- Weekly fasting breath acetone (ketone bodies)
- Follow-up
- Weeks 4 to 8
Primary result
Breath acetone
Between group difference
5.45 parts per million
P = 0.012
As reported in the abstract
Further findings
Breath acetone, first 3 weeks
- Breath acetone increased for the first three weeks without a significant difference between groups
Weight loss
- 14:10 lost more weight than 12:12 (previously reported)
Original publication
Randomized controlled trial of time-restricted eating: secondary analyses of breath acetone. Int J Obes (Lond). Published 11 June 2025. doi:10.
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