Quantitative sensory testing defines the trajectory of sensory neuropathy after severe COVID-19
Authors' conclusion
Severe COVID-19 is associated with abnormal vibration and thermal thresholds which are sustained for up to 1 year in patients with diabetes. Abnormal sensory thresholds have no association with long-COVID development.
Study context
- Population
- Patients with severe COVID-19, aged 68.6 ± 12.4, 18.8 % with diabetes
- Participants
- 32 patients
- Exposure
- Baseline vs 1-year follow-up
- Outcome
- Abnormal VPT, CPT, WPT and HPT on quantitative sensory testing
- Follow-up
- 1-3 weeks of admission and after 1-year
Main finding
As reported in the abstract
Prevalence of abnormal sensory thresholds on the feet · 1-year follow-up
- Abnormal VPT, baseline vs 1 year
- 81.3 % vs 50.0 %, P < 0.01
- Abnormal WPT, baseline vs 1 year
- 81.3 % vs 43.8 %, P < 0.01
- Abnormal heat perception thresholds (HPT), baseline vs 1 year
- 81.3 % vs 50.0 %, P < 0.01
- No change in CPT on the feet
- P = 0.21
- No change in HPT on the face
- P = 1.0
Observational data: associations, not effects.
Further findings
Neuropathic symptoms at baseline
%
- Numbness
- 56.3
- Neuropathic pain
- 43.8
- Abnormal CPT on the feet
- 50.0
- Abnormal HPT on the face
- 12.5
Recovery by diabetes status · 1-year follow-up
- Only participants without diabetes recovered from an abnormal VPT, CPT, and WPT
Long-COVID · baseline
- Long-COVID prevalence
- 37.5 %
- Comparable baseline VPT, WPT and CPT with vs without long-COVID
- P = 0.07-0.69
Original publication
Quantitative sensory testing defines the trajectory of sensory neuropathy after severe COVID-19. Diabetes Res Clin Pract. Published 24 November 2023. doi:10.
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